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Updated: Oct 7, 2025

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Identification of potent α-amylase inhibitors via dynamic combinatorial chemistry
Yao Wu1, Shuang Zhao1, Lei Hu1
1School of Pharmacy, Jiangsu University, 301 Xuefu Rd., Zhenjiang, China.
Abstract:
In this study, we report for the first time the discovery of potent α-amylase inhibitors using principle of dynamic combinatorial chemistry. The best compound identified exhibited not only high inhibitory efficiency but also low cytotoxicity. The binding mode and possible mechanism are determined in the subsequent kinetic and molecular docking studies.
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