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Related Experiment Video

Updated: Oct 7, 2025

Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock

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Published on: November 3, 2023

Gastrointestinal Bleeding in Congenital Bleeding Disorders.

Amir Samii¹, Mahshaad Norouzi², Abbas Ahmadi³

¹Department of Hematology and Blood Transfusion, School of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran.

Seminars in Thrombosis and Hemostasis

|January 12, 2022

Summary

Gastrointestinal bleeding (GIB) in congenital bleeding disorders (CBDs) presents unique challenges due to varied patient responses. This review details current GIB management strategies and alternative therapies for CBDs, focusing on coagulation factor deficiencies and platelet disorders.

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Published on: August 23, 2022

Area of Science:

Gastroenterology
Hematology
Genetics

Background:

Gastrointestinal bleeding (GIB) is a severe condition with diverse presentations in patients with congenital bleeding disorders (CBDs).
Effective management of GIB in CBDs is complicated by phenotypic heterogeneity.
Early identification and assessment are crucial for managing GIB in this population.

Purpose of the Study:

To review current understanding of GIB in CBDs.
To highlight recent findings on prevalence, management, and alternative therapies for GIB related to coagulation factor deficiencies (CFDs) and platelet disorders.

Main Methods:

Literature review focusing on GIB in CBDs.
Analysis of diagnostic approaches, including hematological assessment.
Examination of treatment strategies, including replacement therapy and alternative options.

Main Results:

GIB is rare but severe in CBDs, necessitating precise assessment.
Initial evaluation involves hematological status assessment; GIB must be considered in patients with anemia or specific bleeding symptoms.
Management for high-risk patients includes urgent interventions like replacement therapy for CFDs, though optimal strategies are debated.

Conclusions:

Comprehensive assessment and tailored management are essential for GIB in CBDs.
Further research is needed to clarify the best treatment strategies for CFD-related GIB.
This review synthesizes current knowledge on GIB in CBDs, emphasizing CFDs and platelet disorders.