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Controllable Synthesis of Monodispersed NU-1000 Drug Carrier for Chemotherapy
Xueyan Zhao1,2, Sainan Liu1,3, Chunling Hu1,3
1State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China.
Abstract:
A mesoporous metal-organic framework (MOF) named NU-1000 has received considerable attention in various fields owing to its outstanding stability and large pore size. In this study, NU-1000 particles with different sizes were prepared by varying the kinds of solvents. Attributed to the excellent biocompatibility and large pore volume, about 35 wt % of doxorubicin hydrochloride (DOX) were loaded into the resultant nanoscale NU-1000, and a long-time release behavior for over 2 weeks was realized. The in vivo investigation has shown the advantage of NU-1000 in carrying drugs for chemotherapy attributed to its excellent antitumor efficacy.
