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Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Drugs that Stabilize Microtubules

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Related Experiment Video

Updated: Oct 6, 2025

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

A Dual Drug Delivery Platform for Cancer-Bacteria Cotargeting.

Rohini Singh, Chandra Shekhar Kumar, Manidipa Banerjee

ACS Applied Bio Materials

|January 13, 2022

Summary

This study introduces dualosomes, a novel dual drug delivery platform targeting both cancer cells and bacteria within the tumor microenvironment. This innovative approach significantly enhances the elimination of both cancer and bacterial infections, combating drug resistance.

Keywords:

cancer cotargeting dual-functional liposomes dug resistance intracellular bacteria

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Analysis of Targeted Viral Protein Nanoparticles Delivered to HER2+ Tumors

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Published on: June 18, 2013

Area of Science:

Biomedical Engineering
Nanotechnology
Oncology

Background:

Bacteria can coexist with cancer cells, complicating treatment by affecting chemotherapy and promoting antibiotic resistance.
Current cancer and bacterial therapies are administered separately, leading to suboptimal outcomes in co-infected patients.

Purpose of the Study:

To develop and evaluate a dual drug delivery platform, "dualosome", for simultaneous targeting of cancer cells and bacteria.
To assess the efficacy of dualosomes in eliminating both cancer and bacterial cells in a co-infection model.

Main Methods:

Dualosomes were engineered using liposomes encapsulating doxorubicin (anticancer drug) and displaying a cationic antibacterial peptide (sushi S3) on the surface.
Folic acid was conjugated to the liposomal surface for enhanced cancer cell targeting.
The efficacy of dualosomes was tested on model S. typhi-infected hepatoma (Huh-7) cells.

Main Results:

The dualosome system demonstrated superior efficacy, eliminating both cancer and bacterial cells significantly more effectively than individual drugs.
The enhanced performance is attributed to bacteria-linked doxorubicin activity and improved liposome internalization due to cationic surface charge.
The dualosome platform showed at least 75% greater effectiveness in eliminating both cell types compared to single-agent treatments.

Conclusions:

Dualosomes represent a promising nanoplatform for simultaneously treating cancer and associated bacterial infections.
This dual-targeting approach holds potential for overcoming drug resistance in cancer-bacterial co-infections.
The developed system offers a novel strategy to manage complex tumor microenvironments harboring bacterial pathogens.