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Injectable Biodegradable Multimodal Mammography Marker.

Moran Haim Zada1, S Nahum Goldberg2, Yitschak Nissenbaum2

  • 1Institute of Drug Research, School of Pharmacy-Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel.

ACS Applied Bio Materials
|January 13, 2022
PubMed
Summary
This summary is machine-generated.

Researchers developed an injectable, biodegradable polymer marker (PSA:RA) with contrast agents for temporary tumor imaging. This novel marker offers good visibility across MRI, CT, and ultrasound, with no observed toxicity in mice.

Keywords:
PSA:RA formulationbiocompatibility and biodegradabilitycontrast agentimagingtoxicity

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Area of Science:

  • Biomaterials Science
  • Medical Imaging
  • Polymer Chemistry

Background:

  • Temporary markers are needed for imaging studies, especially when permanent markers are undesirable.
  • Biodegradable injectable markers can improve patient compliance and target specific regions.
  • Current imaging markers lack flexibility and ease of administration.

Purpose of the Study:

  • To develop and evaluate an injectable, biodegradable polymer marker formulation for temporary imaging.
  • To assess the visibility, shape, and degradation characteristics of the marker using MRI, CT, and US.
  • To determine the safety and efficacy of the marker for potential clinical application.

Main Methods:

  • Developed an injectable marker using poly(ricinoleic acid-co-sebacic acid) (PSA:RA) with iodixanol and iron oxide contrast agents.
  • Evaluated marker visibility and characteristics using MRI, CT, and ultrasound in phantom models and ex vivo tissues.
  • Assessed in vivo systemic toxicity by subcutaneous implantation in mice.

Main Results:

  • The PSA:RA formulation demonstrated good visibility across MRI, CT, and US imaging modalities.
  • The marker showed predictable placement and shape characteristics in bovine liver and poultry muscles.
  • No in vivo systemic toxicity symptoms were observed in mice after subcutaneous implantation.

Conclusions:

  • The injectable PSA:RA marker formulation is a promising temporary solution for imaging studies.
  • Its ease of injection and multimodal imaging capability offer advantages for tumor region visualization.
  • The biodegradable nature and safety profile support its potential clinical translation.