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Surface-Functionalized Polypropylene Surgical Mesh for Enhanced Performance and Biocompatibility.

Tanushree Saha1,2, Shadi Houshyar1,2, Satya Ranjan Sarker3,4

  • 1Centre for Materials Innovation and Future Fashion (CMIFF), School of Fashion and Textiles, RMIT University, Brunswick, 3056 Victoria, Australia.

ACS Applied Bio Materials
|January 13, 2022
PubMed
Summary

Surface modification of polypropylene (PP) surgical mesh with 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer enhances biocompatibility. This PMPC-grafted PP mesh shows reduced protein adsorption and improved cell viability, making it a promising biomaterial for surgical applications.

Keywords:
PMPCbiocompatibilitycell attachmentpolypropylene meshprotein adsorptionsurface functionalization

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Surface Engineering

Background:

  • Polypropylene (PP) surgical mesh is widely used due to its inertness and mechanical strength.
  • Enhancing biocompatibility and reducing tissue adhesion are critical for improving PP mesh performance.
  • Current limitations necessitate surface modifications to overcome these challenges.

Purpose of the Study:

  • To improve the biocompatibility of PP surgical mesh through surface modification.
  • To reduce protein adsorption and unwanted tissue adhesion on PP mesh.
  • To optimize the grafting process of 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer onto PP mesh.

Main Methods:

  • Surface modification of plasma-activated PP mesh using MPC polymer.
  • Optimization of reaction time and monomer concentration for PMPC grafting.
  • Characterization using ATR-FTIR, SEM, EDX, contact angle measurements, and BSA protein adsorption assays.
  • Evaluation of cell viability and attachment using MTT assays and microscopy.

Main Results:

  • Successful grafting of PMPC onto plasma-activated PP mesh confirmed by ATR-FTIR and EDX.
  • PMPC-grafted PP mesh exhibited significantly reduced contact angle and bovine serum albumin (BSA) protein adsorption.
  • Optimal results (lowest contact angle, highest protein adsorption reduction) achieved at 0.3 M MPC and 90 min reaction time.
  • MTT assays showed high cell viability (~90%), indicating low toxicity.
  • Microscopy revealed increased resistance to cell attachment on the PMPC-grafted mesh.

Conclusions:

  • Surface modification of PP mesh with PMPC polymer effectively enhances biocompatibility.
  • The optimized PMPC-grafted PP mesh demonstrates reduced protein adsorption and cellular adhesion.
  • This modified PP mesh shows potential as an advanced biomaterial for surgical applications, addressing current clinical needs.