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Related Experiment Video

Updated: Jun 11, 2026

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation
06:57

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Pluronic-Based Nanocarrier Platform Encapsulating Two Enzymes for Cascade Reactions.

Seoungkyun Kim1, Kiyoon Kwon1, Jaehyun Cha1

  • 1School of Materials Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, Republic of Korea.

ACS Applied Bio Materials
|January 13, 2022
PubMed
Summary
This summary is machine-generated.

Pluronic-based nanocarriers efficiently immobilize single enzymes and coimmobilize multiple enzymes. This method enhances enzyme activity and stability for biosensing and synthetic applications.

Keywords:
cascade reactionencapsulationenzymeimmobilizationpluronic-based nanocarrier

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Area of Science:

  • Biotechnology
  • Materials Science

Background:

  • Enzyme immobilization is crucial for applications like biosensing and synthesis.
  • Coimmobilizing multiple enzymes presents challenges in achieving high yield, activity retention, and low leaching.

Purpose of the Study:

  • To develop a pluronic-based nanocarrier (PNC) for efficient enzyme immobilization and coimmobilization.
  • To evaluate the PNC's performance in terms of encapsulation yield, enzyme activity, and leaching.

Main Methods:

  • Utilized a temperature-sensitive pluronic-based nanocarrier (PNC) for enzyme encapsulation.
  • Tested six different enzymes for single immobilization and two enzymes (formate dehydrogenase and mannitol dehydrogenase) for coimmobilization.
  • Assessed immobilization yield, retained enzymatic activity, and enzyme leaching over time.

Main Results:

  • PNC achieved high encapsulation yields (∼90%) and retained high enzymatic activity (>95%) for all tested single enzymes.
  • Enzyme leaching was minimal (<0.13% over 2 weeks).
  • Coimmobilization of formate dehydrogenase and mannitol dehydrogenase in PNC significantly enhanced d-mannitol production (>10-fold increase) compared to free enzymes.

Conclusions:

  • Pluronic-based nanocarriers are effective platforms for single and multiple enzyme immobilization.
  • The PNC system offers high efficiency, activity retention, and stability, making it suitable for cascade reactions and other enzyme applications.