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Atropine Affects the Outer Retina During Inhibiting Form Deprivation Myopia in Guinea Pigs
Hong Liu1,2, Donglong Chen3, Zhikuan Yang1,2,4
1Aier School of Ophthalmology, Central South University, Changsha, Hunan Province, China.
Current Eye Research
|January 13, 2022
Summary
Atropine effectively slows myopia progression by impacting the outer retina, likely cones, in guinea pigs. This study investigated atropine
Area of Science:
- Ophthalmology
- Neuroscience
- Animal Models
Background:
- Atropine is known to inhibit myopia progression, but its mechanism is not fully understood.
- Myopia development involves complex morphological and functional changes in the eye.
Purpose of the Study:
- To investigate the morphological and functional changes induced by atropine during myopia inhibition.
- To elucidate the mechanism of atropine's effect on myopia progression.
Main Methods:
- Form-deprived myopia (FDM) was induced in guinea pigs.
- Intravitreal injections of atropine or saline were administered over two weeks.
- Ocular parameters (refraction, axial length, retinal/choroidal thickness) and electroretinograms (ERG) were analyzed.
Main Results:
- Atropine significantly reduced differences in refractive error, vitreous chamber depth, and axial length compared to saline.
- Outer retinal thickness increased with atropine treatment, while choroidal thickness showed a decreasing trend in the saline group.
- Photopic ERG revealed greater a-wave amplitudes in atropine-treated eyes, suggesting improved retinal function.
Conclusions:
- Atropine's myopia inhibition effect is associated with changes in the outer retina, potentially involving cone photoreceptors.
- These findings provide insights into the cellular mechanisms underlying atropine's efficacy in managing myopia.
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