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Diffuse Large B-Cell Lymphoma in the Setting of Chronic Lymphocytic Leukemia
Mariana Esteves1, Teresa Baudrier2, Ana Carneiro3
1Department of Dermatology and Venereology, Hospitalar Universitário de São João EPE, Porto, Portugal; and Faculty of Medicine, University of Porto, Porto, Portugal; mariana.cbesteves@gmail.com.
Abstract:
A 77-year-old man was referred to our department with a 6-month history of a painless, rapidly enlarging tumor on the left leg. Fourteen years ago, he was diagnosed with chronic lymphocytic leukemia (CLL), and he had presented with lymphocytosis and multiple lymphadenopathies (Rai stage II). Both bone marrow aspiration and peripheral blood immunophenotyping identified a monoclonal B-cell population expressing surface CD5, CD20, CD23, CD43, and IgG kappa. At that time, he underwent eight courses of treatment with oral fludarabine, followed by complete remission, and he had been clinically stable ever since (Rai stage 0).
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