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Immuno-oncology trends: preclinical models, biomarkers, and clinical development

Maryland Rosenfeld Franklin1, Suso Platero1, Kamal S Saini1

  • 1Labcorp Drug Development Inc, Princeton, New Jersey, USA.

Journal for Immunotherapy of Cancer
|January 13, 2022
PubMed

Insights

Immuno-oncology (I-O) drug development is advancing rapidly. Key tools like preclinical models, biomarkers, and adaptive clinical trial designs are crucial for efficiently bringing new cancer immunotherapies from the lab to patients.

Area of Science:

  • Oncology
  • Immunology
  • Drug Development

Background:

  • The field of immuno-oncology (I-O) has seen significant evolution.
  • Thousands of I-O therapies and combinations are in development pipelines and clinical trials.
  • Efficient development necessitates advanced tools and technologies.

Purpose of the Study:

  • To provide an overview of critical tools for immuno-oncology drug development.
  • To highlight how novel discoveries in key areas can improve cancer patient management.

Main Methods:

  • Discussion of essential preclinical models for evaluating I-O therapies.
  • Overview of biomarkers for pharmacodynamic, predictive, and monitoring utility.
  • Exploration of evolving clinical trial designs for efficient evaluation.

Main Results:

  • Novel discoveries in preclinical models enhance early-stage assessment.
  • Biomarkers provide crucial insights into treatment response and patient selection.
  • Innovative clinical trial designs accelerate the evaluation of I-O agents.

Conclusions:

  • Investment in and utilization of appropriate tools are vital for successful I-O asset development.
  • Advancements in models, biomarkers, and trial designs hold potential for addressing unmet clinical needs in cancer.
  • These integrated approaches are key to advancing patient care in immuno-oncology.
Keywords:
antigenic modulationbiomarkersclinical trials as topicimmune toleranceimmunotherapytumor

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