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Author Spotlight: Elucidating the Pathways of TFH Cell Differentiation in Acute LCMV Challenges
Published on: April 26, 2024
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B cell-derived IL-27 promotes control of persistent LCMV infection
Isaraphorn Pratumchai1,2, Jaroslav Zak1, Zhe Huang1
1Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037.
Summary
B cells produce interleukin-27 (IL-27), crucial for controlling persistent lymphocytic choriomeningitis virus (LCMV) infection. This cytokine supports T cell survival and function, enhancing antiviral immunity and antibody responses.
Area of Science:
- Immunology
- Virology
- Cell Biology
Background:
- B cell-derived cytokines are key regulators of immune responses.
- The role of B cells in producing interleukin-27 (IL-27) during viral infections is not fully understood.
Purpose of the Study:
- To investigate the role of B cell-derived IL-27 in regulating adaptive immunity during persistent lymphocytic choriomeningitis virus (LCMV) clone 13 (Cl-13) infection.
- To elucidate the mechanisms by which B cell-derived IL-27 influences T cell responses and viral control.
Main Methods:
- Utilized conditional knockout mouse models with specific IL-27p28 deletion in B cells.
- Assessed the impact of IL-27 signaling on CD4 T cell survival, T follicular helper (Tfh) cell function, and antibody class switching.
- Examined the necessity of IL-27 receptor alpha (IL-27ra) signaling in T cells for viral control.
Main Results:
- B cells were identified as a significant source of IL-27 during persistent LCMV Cl-13 infection.
- B cell-derived IL-27 was shown to promote the survival and function of virus-specific CD4 T cells and Tfh cells.
- IL-27 signaling in T cells was essential for effective viral control, optimal CD4 T cell responses, and antibody class switching.
Conclusions:
- B cell-derived IL-27 plays a critical role in driving antiviral immunity against persistent LCMV infection.
- B cell-derived IL-27 acts on T cells via IL-27 receptor signaling to enhance CD4 T cell responses, antibody production, and viral clearance.
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