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Immunostimulation in recurrent respiratory tract infections therapy in children

W Prusek1, A Jankowski, G Radomska

  • 1Department of Pediatrics, Regional Hospital, Wrocław.

Archivum Immunologiae Et Therapiae Experimentalis
|January 1, 1987
PubMed

Insights

Immunotherapy effectively treated recurrent respiratory tract infections in children by boosting T cells. Treatments like TFX and Levamisol showed the most positive results, improving immune function.

Area of Science:

  • Pediatrics
  • Immunology
  • Infectious Diseases

Background:

  • Recurrent respiratory tract infections (RRTIs) in children are often linked to depressed T lymphocyte counts, similar to conditions seen in AIDS patients.
  • Elevated serum IgM concentrations were also observed in affected children.

Purpose of the Study:

  • To evaluate the effectiveness of various immunotherapies in managing RRTIs in children.
  • To assess changes in immunologic parameters following different treatment modalities.

Main Methods:

  • A study involving 117 children aged 12 months to 10 years with RRTIs.
  • Treatment groups received TFX, Levamisol, Broncho-Vaxom, PADMA, or climatotherapy; a control group received no immunostimulants.
  • Immunologic parameters, including T lymphocyte counts and serum IgM, were monitored.

Main Results:

  • All investigated treatments demonstrated beneficial effects on RRTIs.
  • TFX and Levamisol yielded the highest percentage of positive outcomes.
  • An increase in T cells percentage was observed across all treatment groups, most notably with Levamisol.

Conclusions:

  • Immunotherapies, particularly TFX and Levamisol, are effective in treating RRTIs in children.
  • While T cell percentages increased with treatment, no direct correlation was found between T cell numbers and clinical improvement.

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