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Updated: Oct 6, 2025
MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening
Published on: October 26, 2017
Sensitive electrochemiluminescence analysis of lung cancer marker miRNA-21 based on RAFT signal amplification
Qingyu Wang1,2, Shuaibing Yu1, Lianshun Zhang2
1School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing 210094, P. R. China. kong@njust.edu.cn.
Abstract:
An electrochemiluminescence approach based on surface-initiated reversible addition-fragmentation chain transfer (SI-RAFT) was developed for miRNA-21 detection for the first time. The SI-RAFT polymerization generates polymer chains with functional groups that are used to recruit luminol, enabling strong ECL signal output with low concentrations of miRNA-21, and greatly improving the detection sensitivity.
