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Related Experiment Video

Updated: Oct 6, 2025

Author Spotlight: Advancing Hepatic Fibrosis Diagnosis Using Magnetic Resonance Elastography and AI

Author Spotlight: Advancing Hepatic Fibrosis Diagnosis Using Magnetic Resonance Elastography and AI

Published on: July 21, 2023

Liver fibrosis quantification.

Sudhakar K Venkatesh¹, Michael S Torbenson²

¹Abdominal Imaging Division, Department of Radiology, Mayo Clinic, 200, First Street SW, Rochester, MN, 55905, USA. venkatesh.sudhakar@mayo.edu.

Abdominal Radiology (New York)

|January 13, 2022

Summary

This summary is machine-generated.

Liver fibrosis (LF) is a key outcome of chronic liver disease. Non-invasive tests (NITs) are increasingly used to assess LF, complementing or replacing liver biopsy for staging and treatment evaluation.

Keywords:

Diffusion Elastography Fibrosis burden Hepatic fibrosis Hepatobiliary uptake Imaging biomarkers Non-invasive tests Surface nodularity Susceptibility T1-mapping Volumetry

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Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

Published on: March 24, 2023

Area of Science:

Hepatology
Radiology
Biomarkers

Background:

Liver fibrosis (LF) represents the chronic liver disease (CLD) endpoint, significantly impacting patient outcomes.
Accurate LF quantification is crucial for staging, treatment response assessment, and prognosis.
Liver biopsy, the traditional method, has limitations including invasiveness and sampling errors.

Purpose of the Study:

To review the pathogenesis and evolution of LF in various CLDs.
To discuss the role and properties of imaging biomarkers for LF assessment.
To provide context for the clinical application of non-invasive tests (NITs) in LF evaluation.

Main Methods:

Review of existing literature on LF pathogenesis, staging, and non-invasive assessment.
Discussion of imaging biomarker properties and their correlation with LF.
Comparison of traditional liver biopsy with emerging NITs.

Main Results:

Non-invasive tests (NITs), including serum tests and imaging biomarkers like elastography, are gaining clinical importance.
NITs are validated against liver biopsy and are expected to be widely used for CLD evaluation.
Several imaging biomarkers are under research and development for future clinical application.

Conclusions:

Understanding LF pathogenesis is vital for interpreting imaging biomarker data.
Abdominal radiologists need to understand the properties measured by imaging biomarkers and their relation to LF.
NITs are poised to become the standard for LF evaluation, reserving liver biopsy for specific cases.