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[Neurohormonal and immunological status of patients with autoimmune thrombocytopenic purpura]
A study was made of the relationship between hormonal (ACTH, cortisol, TSH, T3, T4, STH) and immune (E-RFC, EAC-RFC, and immunoglobulins) shifts in the time course of therapy in 106 patients with autoimmune thrombocytic purpura. A significant decrease in the level of T3 and its direct correlation with E-RFC in exacerbation of disease combined with an increase in the levels of cortisol and IgM were revealed. The treatment with glucocorticoids and immunosuppressants resulted in a more noticeable decrease in the levels of T3 and E-RCF. In case of development of hematological remission splenectomy resulted in the normalization of these shifts. In splenectomized patients with immunosuppressive therapy-refractory recurrences there was again a decrease in the level of T3 whereas the level of E-RCF was even on an increase.
A study was made of the relationship between hormonal (ACTH, cortisol, TSH, T3, T4, STH) and immune (E-RFC, EAC-RFC, and immunoglobulins) shifts in the time course of therapy in 106 patients with autoimmune thrombocytic purpura. A significant decrease in the level of T3 and its direct correlation with E-RFC in exacerbation of disease combined with an increase in the levels of cortisol and IgM were revealed. The treatment with glucocorticoids and immunosuppressants resulted in a more noticeable decrease in the levels of T3 and E-RCF. In case of development of hematological remission splenectomy resulted in the normalization of these shifts. In splenectomized patients with immunosuppressive therapy-refractory recurrences there was again a decrease in the level of T3 whereas the level of E-RCF was even on an increase.