Related Experiment Video
Updated: Jul 6, 2026
12:45
Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
Published on: December 11, 2017
Risk factors for developing pacing induced LV dysfunction: Experience from a tertiary center in the UK
Vijayabharathy Kanthasamy1, Nikolaos Papageorgiou1,2, Tomi Bajomo1
1Barts Heart Centre, St Bartholomew's Hospital, West Smithfield, London, UK.
Pacing and Clinical Electrophysiology : PACE
|January 13, 2022
Summary
Atrial fibrillation, borderline low systolic function, and male gender predict pacing-induced left ventricular dysfunction in patients with high right ventricular pacing burden. Early LVD development is linked to age and borderline low systolic function.
Area of Science:
- Cardiology
- Electrophysiology
- Heart Failure
Background:
- Understanding risk factors for pacing-induced left ventricular dysfunction (LVD) in patients with high right ventricular pacing (RVP) burden is crucial.
- Left ventricular dysfunction can significantly impact patient outcomes and quality of life.
Purpose of the Study:
- To identify the determinants of pacing-induced LVD in patients receiving significant RVP.
- To assess predictors for the development and timing of LVD.
Main Methods:
- Retrospective analysis of 146 patients with RVP > 40% undergoing generator change or CRT upgrade.
- Patients initially had preserved left ventricular ejection fraction (EF) ≥50%.
Main Results:
- Atrial fibrillation (AF), borderline low systolic function (BLSF), and male gender independently predicted RVP-induced LVD.
- Increasing age and BLSF were associated with earlier LVD development post-implant.
Conclusions:
- AF, BLSF, and male gender are key predictors of pacing-induced LVD in high RVP burden patients.
- LVD can manifest anytime after pacemaker implantation, with age and BLSF influencing the onset.
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