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Correlations between rotational thromboelastometry (ROTEM) and standard coagulation tests following viper snakebites
Xuan Thi Dang1,2, Thanh Xuan Nguyen3,4,5, Huong Thi Thu Nguyen3,4
1Vietnam Poison Control Center, Bach Mai Hospital, Hanoi, Vietnam.
The Journal of International Medical Research
|January 13, 2022
Summary
Rotational thromboelastometry (ROTEM) effectively identified hypocoagulation in viper snakebite patients. This rapid test showed moderate correlations with standard coagulation tests, aiding in patient assessment.
Area of Science:
- Clinical toxicology
- Hematology
- Diagnostic techniques
Background:
- Viper snakebites frequently cause consumption coagulopathy.
- Rotational thromboelastometry (ROTEM) offers rapid assessment of coagulation disorders.
Purpose of the Study:
- To investigate the relationship between ROTEM parameters and conventional coagulation tests.
- To evaluate ROTEM's utility in viper envenomation.
Main Methods:
- Prospective observational study of 41 viper envenomation patients.
- Collected standard coagulation tests (PT, aPTT, fibrinogen, platelets) and ROTEM (CT, MCF) data.
- Analyzed ROTEM using EXTEM, INTEM, and FIBTEM assays.
Main Results:
- ROTEM revealed prolonged clotting times and reduced clot firmness in a significant proportion of patients.
- Moderate correlations found between PT and EXTEM CT (r=0.627), aPTT and INTEM CT (r=0.626).
- Stronger correlations observed between fibrinogen and FIBTEM MCF (r=0.723), and platelet count and EXTEM MCF (r=0.60).
Conclusions:
- ROTEM indicates a hypocoagulation state in viper snakebite victims.
- ROTEM findings correlate moderately with standard coagulation tests, supporting its clinical use.
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