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Updated: Aug 9, 2026

An Endothelial Planar Cell Model for Imaging Immunological Synapse Dynamics
Published on: December 24, 2015
A model of T cell-target interaction leading to lymphokine release
1Department of Physiology, John Curtin School of Medical Research, Australian National University, Canberra.
Abstract:
Binding of antigenic cells by activated T lymphocytes can trigger the release of a number of soluble factors, including the lymphokine interleukin 3 (IL3). The cellular interactions between T cells and allogeneic cells which are involved in the triggering of lymphokine release from T cells are still poorly understood. We have examined the relationship between antigenic cell number, T cell number and IL3 release and have derived a steady state binding model which adequately accounts for the experimental data if it is assumed that triggering is an all or none phenomenon. We find that binding of at least two antigenic cells by an allo-reactive T cell is necessary to trigger lymphokine release.
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