Development of an Insulin Nano-delivery System through Buccal Administration

Area of Science:

• Pharmaceutical Sciences
• Biomaterials Engineering
• Drug Delivery Systems

Background:

• Biodegradable polymeric nanoparticles (PNPs) are crucial in advanced drug delivery.
• PNPs aim to maximize therapeutic effects by targeting drug action sites.
• This study focuses on overcoming limitations of traditional insulin delivery methods.

Purpose of the Study:

• To develop an insulin-consumable nano-delivery system for buccal administration.
• To enhance the mucoadhesive properties of the delivery system.
• To achieve sustained insulin release through mucoadhesion.

Main Methods:

• Utilized a water-oil-water (W-O-W) microemulsion solvent evaporation technique.
• Prepared positively charged poly(D,L-lactide-co-glycolide) nanoparticles coated with chitosan and loaded with insulin.
• Developed a consumable buccal film using spin coating to encapsulate the nanoparticles.

Main Results:

• Characterized nanoparticles using SEM, AFM, zeta potential, and FTIR.
• Demonstrated controlled and sustained in vitro insulin release over 6 hours.
• Buccal film formulation showed significantly reduced cumulative insulin release (28.9%) compared to nanoparticles alone (50%).

Conclusions:

• The developed buccal film effectively acts as a barrier, controlling insulin release.
• The nano-delivery system demonstrates potential for sustained buccal insulin delivery.
• This approach offers an improved method for insulin administration via the buccal route.