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The relationship between immature platelet fraction and severity of acute bronchiolitis

Murat Doğan1, Mehmet Köse2, Mehmet Adnan Öztürk1

  • 1Departments of Pediatric Emergency, Erciyes University Faculty of Medicine, Kayseri, Turkey.

The Turkish Journal of Pediatrics
|January 13, 2022
PubMed

Insights

Immature platelet fraction (IPF) can help assess acute bronchiolitis severity in infants. Higher IPF levels correlate with increased severity, offering a valuable diagnostic tool for this common childhood illness.

Area of Science:

  • Pediatrics
  • Hematology
  • Clinical Diagnostics

Background:

  • Acute bronchiolitis is a frequent cause of infant hospitalization.
  • While generally benign, severe cases can be fatal.
  • Early identification of severity is crucial for timely intervention.

Purpose of the Study:

  • To investigate the immature platelet fraction (IPF) as a biomarker for acute bronchiolitis severity.
  • To compare IPF's diagnostic capacity against other hematological parameters.

Main Methods:

  • 179 infants with acute bronchiolitis were classified into mild, moderate, and severe groups.
  • A control group of 80 healthy children was included.
  • Receiver operating characteristic (ROC) curve analysis evaluated IPF and other hematological parameters (PDW, MPV, WBC, PLT).

Main Results:

  • IPF was significantly elevated in bronchiolitis patients compared to controls (p < 0.001).
  • A positive correlation existed between clinical severity and IPF levels.
  • IPF demonstrated high diagnostic accuracy (AUC > 0.84, sensitivity 84%, specificity 97%) for predicting severity, outperforming other parameters.

Conclusions:

  • IPF serves as a reliable indicator for diagnosing and evaluating the clinical severity of acute bronchiolitis in children.
  • IPF measurement can aid clinicians in risk stratification and management decisions.
Abstract

Keywords:
acute bronchiolitischildrenimmature platelet fraction

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