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Related Experiment Videos

T4 lymphopenia in human tuberculosis.

J K Onwubalili1, A J Edwards, L Palmer

  • 1Division of Communicable Disease, MRC Clinical Research Centre, Harrow, Middlesex.

Tubercle
|September 1, 1987
PubMed
Summary
This summary is machine-generated.

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Active tuberculosis significantly reduces T4 and B lymphocytes, impacting immune response. Chemotherapy effectively restored normal lymphocyte levels in patients with tuberculosis.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Hematology

Background:

  • Tuberculosis (TB) is a significant global health challenge.
  • Understanding the impact of TB on the immune system is crucial for effective treatment.
  • Lymphocyte subpopulations play a key role in cell-mediated immunity against infections like TB.

Purpose of the Study:

  • To investigate alterations in lymphocyte subpopulations in patients with active tuberculosis.
  • To compare lymphocyte profiles between TB patients and healthy controls.
  • To assess the effect of chemotherapy on lymphocyte restoration in TB patients.

Main Methods:

  • Studied lymphocyte subpopulations in vitro using immunofluorescence and monoclonal antibodies.
  • Analyzed 13 patients with bacteriologically-proven tuberculosis and 12 matched controls.

Related Experiment Videos

  • Quantified absolute numbers of total T, T4, T8, and B lymphocytes.

    • Main Results:

    • Active tuberculosis was associated with significant reductions in total T (Leu 4+), T4 (Leu 3a+), and B (Leu 12+) lymphocytes.
    • No significant differences were observed in total T8 (Leu 2a+) lymphocyte counts between groups.
    • Two patients exhibited profound T4-lymphopenia, leading to a reversed T4:T8 ratio (<1.2).
    • These immune changes were independent of radiological disease extent or Mantoux reaction size.
    • Chemotherapy led to the restoration of normal lymphocyte levels.

    Conclusions:

    • Active tuberculosis significantly impacts T4 and B lymphocyte populations.
    • T4-lymphopenia and altered T4:T8 ratios are observed in some TB patients.
    • Immune reconstitution occurs with effective chemotherapy treatment.
    • Lymphocyte subpopulation analysis can be a valuable tool in monitoring TB disease activity and treatment response.