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Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid
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Dermal Pathology in Melasma: An Update Review
Kachanat Phansuk1, Vasanop Vachiramon1, Natthachat Jurairattanaporn1
1Division of Dermatology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Clinical, Cosmetic and Investigational Dermatology
|January 13, 2022
Summary
Dermal changes in melasma, including basement membrane disruption and increased melanophages, offer new therapeutic targets. Understanding these interconnected findings is key for effective melasma treatment.
Area of Science:
- Dermatology
- Pathophysiology
- Aesthetic Medicine
Background:
- Melasma is a complex skin condition with challenging treatment outcomes.
- Recent research highlights the role of dermal elements in melasma pathophysiology.
- Existing data on dermal findings in melasma lack integration.
Purpose of the Study:
- To review and discuss dermal findings in melasma lesions.
- To explore potential treatment strategies targeting dermal changes.
- To provide an integrated perspective on melasma's dermal pathology.
Main Methods:
- Comprehensive literature search across major databases (MEDLINE, Embase, Scopus, Google Scholar).
- Inclusion of English-language articles published up to June 2021.
- Analysis of reference lists for additional relevant studies.
Main Results:
- Common dermal findings include basement membrane disruption, pendulous melanocytes, solar elastosis, increased melanophages, mast cells, and neovascularization.
- These dermal alterations exhibit interconnected mechanisms.
- Specific dermal changes correlate with melasma development and progression.
Conclusions:
- Dermal changes in melasma are linked to epidermal pathological alterations.
- Targeting these dermal and epidermal changes offers potential therapeutic avenues.
- A multimodal treatment approach is essential for effective melasma management.
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