Related Experiment Video

Updated: Oct 6, 2025

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
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Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

Published on: February 17, 2022

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Novel biologic therapies in relapsed or refractory diffuse large B cell lymphoma: CAR-T is not the only answer

Jérôme Paillassa1, Firas Safa1

  • 1Service des maladies du sang, Centre Hospitalier Universitaire D'Angers France.

Leukemia Research Reports
|January 13, 2022
PubMed

Insights

Patients with refractory or relapsed diffuse large B-cell lymphoma face poor prognoses. Novel biologic therapies and ongoing clinical trials offer new hope beyond conventional treatments and chimeric antigen receptor T-cell therapy.

Area of Science:

  • Hematology
  • Oncology
  • Immunotherapy

Background:

  • Diffuse large B-cell lymphoma (DLBCL) that is refractory or relapsed after first-line treatment has a poor prognosis with conventional therapies.
  • Chimeric antigen receptor T-cell therapy (CAR-T) is a notable novel targeted therapy, but not all patients are eligible due to risks and availability.

Purpose of the Study:

  • To review promising novel biologic therapies for refractory or relapsed DLBCL.
  • To discuss ongoing clinical trials in this therapeutic area.

Main Methods:

  • Literature review of recent advancements in biologic therapies for DLBCL.
  • Overview of current clinical trials investigating novel treatments.

Main Results:

  • Emerging novel biologic therapies show promise for patients with refractory or relapsed DLBCL.
  • Several ongoing clinical trials are evaluating these new treatment modalities.

Conclusions:

  • Novel biologic therapies represent a significant advancement for patients with refractory or relapsed DLBCL.
  • Further research and clinical trials are crucial to expand treatment options and improve outcomes for these patients.
Keywords:
Antibody drug conjugatesBispecific antibodiesDiffuse large B cell lymphomaImmunotherapyNovel agents

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