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Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
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Updated: Oct 6, 2025

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
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Intermittent fasting & performance: The iFast clinical trial protocol.

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  • 1Department of Emergency Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

Contemporary Clinical Trials Communications
|January 13, 2022
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Summary

Intermittent fasting may improve cardiovascular performance and health markers. This study investigated the effects of intermittent fasting and exercise on VO2 max and other health parameters over 12 weeks.

Keywords:
Aerobic exerciseExercise performanceFATMAXHealth biomarkersIntermittent fastingMaximal oxygen consumptionNutritionSports medicineVO2maxWeight loss

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Area of Science:

  • Exercise Physiology
  • Nutritional Science
  • Human Health

Background:

  • Growing evidence suggests fasting benefits disease prevention, weight control, and longevity.
  • Limited research compares exercise performance between intermittent fasting (IF) and non-fasting individuals.
  • The popularity of IF necessitates understanding its impact on physical performance.

Purpose of the Study:

  • To investigate if intermittent fasting improves cardiovascular performance over 12 weeks using VO2 max measurements.
  • To assess variations in health parameters, physical performance, and biomarkers influenced by IF.
  • To compare the effects of IF with and without exercise against exercise alone and a control group.

Main Methods:

  • Recruitment of participants from a Lebanese university community.
  • Randomization into four groups: IF with exercise, IF without exercise, exercise without fasting, and control.
  • Collection of baseline biological, physical, nutritional, medical, and psychological data.

Main Results:

  • VO2 max measurements to assess cardiovascular performance changes.
  • Repeated measurements throughout the 12-week study period.
  • Data analysis to evaluate the impact of different interventions on various health parameters.

Conclusions:

  • The study aims to provide insights into the effects of intermittent fasting on exercise performance and overall health.
  • Findings will contribute to understanding the role of IF in health and fitness.
  • Results will inform individuals and health professionals about the potential benefits and impacts of IF.