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Rivaroxaban, a Direct Oral Factor Xa Inhibitor, Attenuates Atherosclerosis by Alleviating Factor Xa-PAR2-Mediated

Yusuke Ito1,2, Yasuhiro Maejima1, Shun Nakagama1

  • 1Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan.

JACC. Basic to Translational Science
|January 13, 2022
PubMed

Keywords:
7KC, 7-ketocholesterolApoE–/–, apolipoprotein E deficientBSA, bovine serum albuminCAD, coronary artery diseaseCQ, chloroquineELISA, enzyme-linked immunosorbent assayFBS, fetal bovine serumHFD, high-fat dietIL, interleukinNLRP3, NLR family pyrin domain containing 3PAR2, protease-activated receptor 2PB, phosphate bufferPBS, phosphate-buffered salinePLA, proximity ligation assayPT, prothrombin timeWT, wild typeatherosclerosisautophagyfactor XainflammasomemTOR, mammalian target of rapamycinrivaroxaban

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