Broad virus inactivation using inorganic micro/nano-particulate materials

Area of Science:

• Materials Science
• Virology
• Nanotechnology

Background:

• Disinfection against viral particles often relies on impractical methods.
• Developing effective, broad-spectrum antiviral materials is crucial for public health.
• Inorganic materials offer a promising alternative for continuous decontamination.

Purpose of the Study:

• To develop and evaluate novel inorganic materials for disabling virus infectivity.
• To assess the antiviral efficacy of a new soda-lime glass (G3) and kaolin-based metal nanoparticles (Ag or CuO).
• To investigate the potential of these materials as disinfectants against various viruses, including SARS-CoV-2.

Main Methods:

• Synthesis of a novel soda-lime glass (G3).
• Incorporation of silver (Ag) or copper oxide (CuO) nanoparticles into kaolin.
• Testing antiviral activity against vesicular stomatitis virus (VSV), herpes simplex virus type 1 (HSV-1), adenovirus, influenza virus, and SARS-CoV-2.

Main Results:

• G3 glass and kaolin-containing nanoparticles demonstrated strong antiviral properties.
• Near 99% reduction in VSV infectivity within 10 minutes of contact.
• Over 99% reduction in infectivity for HSV-1, Adenovirus, VSV, Influenza virus, and SARS-CoV-2.

Conclusions:

• The novel inorganic materials exhibit potent, broad-spectrum virucidal activity.
• Antiviral effects are attributed to direct material-virus interaction and leached elements.
• Low-cost kaolin-based materials with controlled nanoparticle release offer a viable strategy for pandemic threats.