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Presentation and outcomes of sepsis in the cardiac intensive care unit

Elizabeth Willa Feldman1, Eunice Dugan1, Robert Scott Stephens2

  • 1Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

American Heart Journal Plus : Cardiology Research and Practice
|January 13, 2022
PubMed

Insights

Sepsis in cardiac intensive care units (CICU) is rising. While CICU patients had fewer acute organ failures, their outcomes were similar to other ICUs, highlighting a need for targeted cardiac sepsis research.

Area of Science:

  • Critical Care Medicine
  • Cardiology
  • Infectious Diseases

Background:

  • Sepsis incidence is increasing in specialized intensive care units, including cardiac intensive care units (CICUs).
  • Clinical profiles and outcomes of sepsis patients within CICUs remain poorly understood.

Purpose of the Study:

  • To compare the clinical characteristics and outcomes of sepsis patients in CICUs versus other intensive care units (ICUs).
  • To identify specific challenges and needs for managing sepsis in cardiac critical care settings.

Main Methods:

  • Retrospective cohort study utilizing the PROGRESS registry.
  • Comparison of sepsis patients admitted to CICUs versus other ICUs.

Main Results:

  • CICU sepsis patients were older, presented with fewer acute organ failures (median 2 vs. 3), and had lower SOFA scores (median 7 vs. 9) but more comorbidities.
  • Treatment modalities including fluid resuscitation, mechanical ventilation, and renal replacement were similar between groups.
  • Mortality rates were comparable: 47.3% for CICU sepsis patients versus 43.6% for sepsis patients in other ICUs (P = 0.37).

Conclusions:

  • Sepsis in CICU patients has outcomes comparable to sepsis in other ICUs, despite presenting with fewer acute organ failures and more chronic comorbidities.
  • Current data suggests a critical need for contemporary research and novel interventions specifically for cardiac patients with sepsis.

Keywords:
Cardiac intensive care unitCardiologyCritical careSepsisShock

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