Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neuroplasticity01:01

Neuroplasticity

904
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
904
Testosterone: Functions and Regulation01:26

Testosterone: Functions and Regulation

1.2K
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
1.2K
Drugs Affecting Neurotransmitter Synthesis01:29

Drugs Affecting Neurotransmitter Synthesis

1.7K
Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase,...
1.7K
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

1.2K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
1.2K
Neural Regulation01:37

Neural Regulation

40.5K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
40.5K
Signs of Puberty01:27

Signs of Puberty

718
Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
718

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluating the Impact of Pharmacist-Based Models of Care on Treatment Retention Among Individuals With Opioid Use Disorder: A Systematic Review and Meta-Analysis.

Journal of addiction medicine·2026
Same author

CMS Proposed Restrictions on Peripheral Nerve Blocks and Procedures for Chronic Pain: Clinical, Ethical, and Policy Implications for Millions of Americans.

Pain medicine (Malden, Mass.)·2026
Same author

Lessons learned from the INTEGRATE-Pain Delphi process to develop core outcome sets (COS) across the pain continuum.

Pain medicine (Malden, Mass.)·2025
Same author

Cannabidiol (CBD) potentiates physiological and behavioral markers of hypothalamic-pituitary-adrenal (HPA) axis responsivity in female and male mice.

Psychopharmacology·2025
Same author

The Lysine Acetyltransferase PCAF Functionally Interacts with Estrogen Receptor Alpha in the Hippocampus of Gonadally Intact Male-But Not Female-Rats to Enhance Short-Term Memory.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2024
Same author

Developing consensus on core outcome sets of domains for acute, the transition from acute to chronic, recurrent/episodic, and chronic pain: results of the INTEGRATE-pain Delphi process.

EClinicalMedicine·2023

Related Experiment Video

Updated: Oct 6, 2025

Sex Stratified Neuronal Cultures to Study Ischemic Cell Death Pathways
10:44

Sex Stratified Neuronal Cultures to Study Ischemic Cell Death Pathways

Published on: December 9, 2013

12.1K

Androgen Effects on Neural Plasticity.

Nariko Kuwahara1, Kate Nicholson1, Lauren Isaacs1

  • 1Department of Biomedical Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada.

Androgens: Clinical Research and Therapeutics
|January 13, 2022
PubMed
Summary

Androgens impact brain structure and function, influencing neurological disorders like autism and Alzheimer's disease. This review focuses on androgen's neuroplastic effects, particularly in the hippocampus.

Keywords:
gliahippocampusneurosteroidogenesissynaptogenesistestosterone

More Related Videos

Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice
09:35

Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice

Published on: January 20, 2015

8.9K
Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice
05:44

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice

Published on: October 13, 2023

1.6K

Related Experiment Videos

Last Updated: Oct 6, 2025

Sex Stratified Neuronal Cultures to Study Ischemic Cell Death Pathways
10:44

Sex Stratified Neuronal Cultures to Study Ischemic Cell Death Pathways

Published on: December 9, 2013

12.1K
Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice
09:35

Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice

Published on: January 20, 2015

8.9K
Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice
05:44

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice

Published on: October 13, 2023

1.6K

Area of Science:

  • Neuroendocrinology
  • Neuroscience
  • Neurobiology

Background:

  • Androgens are synthesized in the brain, gonads, and adrenal glands.
  • They exert significant physiological effects on central nervous system structure and function.
  • Differential rates of neurological disorders in males and females suggest a role for sex hormones.

Purpose of the Study:

  • To review the neuroplastic effects of androgens.
  • To highlight the role of androgens in neurological disorders.
  • To focus on androgen effects within the hippocampus.

Main Methods:

  • Literature review of existing research on androgens and neuroplasticity.
  • Focus on studies investigating androgen influence on the central nervous system.
  • Emphasis on research concerning the hippocampus.

Main Results:

  • Androgens play a crucial role in modulating neuroplasticity.
  • Evidence suggests androgen involvement in the pathophysiology of autism spectrum disorder, schizophrenia, and Alzheimer's disease.
  • The hippocampus is a key brain region affected by androgen action.

Conclusions:

  • Androgens significantly influence brain structure and function, impacting neuroplasticity.
  • Understanding androgen's neurobiological effects is vital for addressing sex-based disparities in neurological disorders.
  • Further research on androgen-hippocampal interactions is warranted.