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Eukaryotic initiation factor 6 regulates mechanical responses in endothelial cells

Adam N Keen1,2, Luke A Payne1,2, Vedanta Mehta1,2

  • 1Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

The Journal of Cell Biology
|January 13, 2022
PubMed
Summary

The eukaryotic initiation factor 6 (eIF6) regulates cellular mechanics by stabilizing key signaling proteins. Loss of eIF6 reduces cell stiffness and causes cytoskeletal defects, revealing a novel link between protein translation and mechanotransduction.

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