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An external validation study of the Utah Bleeding Risk Score

Armin Peivandi1, Henryk Welp1, Mirela Scherer1

  • 1Department of Cardiothoracic Surgery, University Hospital Muenster, Muenster, Germany.

European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association for Cardio-Thoracic Surgery
|January 13, 2022
PubMed

Insights

The Utah Bleeding Risk Score (UBRS) could not predict gastrointestinal bleeding (GIB) in continuous-flow left ventricular assist device (CF-LVAD) patients. Coronary artery disease may increase GIB risk during CF-LVAD support.

Area of Science:

  • Cardiology
  • Gastroenterology
  • Medical Devices

Background:

  • Gastrointestinal bleeding (GIB) is a significant complication in patients with continuous-flow left ventricular assist devices (CF-LVAD).
  • The Utah Bleeding Risk Score (UBRS) was developed to predict GIB in CF-LVAD patients.

Purpose of the Study:

  • To externally validate the predictive ability of the UBRS in a cohort of CF-LVAD patients.
  • To assess the applicability of the UBRS for predicting GIB in this population.

Main Methods:

  • The UBRS was calculated for 111 CF-LVAD patients.
  • GIB events were summarized, and patients were stratified into risk groups.
  • Predictive ability was examined using receiver operating characteristic curve analysis at 3 years and during the entire support period.

Main Results:

  • The UBRS showed poor predictive ability (AUC < 0.52) for GIB at 3 years and during the whole support time.
  • No significant difference in UBRS was observed between patients with and without GIB.
  • Coronary artery disease was associated with an increased risk of GIB beyond the third year of support.

Conclusions:

  • The UBRS is not applicable for predicting GIB in this cohort of CF-LVAD patients.
  • Coronary artery disease may be a risk factor for GIB in CF-LVAD patients.
  • Further validation in a larger cohort is recommended.
Abstract

Keywords:
Continuous-flow left ventricular assist deviceGastrointestinal bleedingHeart failureUtah Bleeding Risk Score

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