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F-box only protein 9 and its role in cancer

Shujaat Hussain1,2,3,4,5, Jianshu Dong6,7,8,9,10, Xinli Ma11

  • 1School of Pharmaceutical Sciences, Zhengzhou University, No 100 Kexue Dadao, Gaoxin District, Zhengzhou, 450001, China.

Molecular Biology Reports
|January 13, 2022
PubMed

Insights

F-box proteins (FBPs) are crucial for protein degradation and linked to cancer. This review details FBXO9

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • F-box proteins (FBPs) are key components of SCF E3 ligase complexes, regulating protein ubiquitylation and degradation.
  • Dysregulation of FBP-mediated proteolysis is implicated in human malignancies.
  • FBXO9, an F-box protein, exhibits varied expression and function across different human cancers.

Purpose of the Study:

  • To review the role of FBXO9 in various human cancers.
  • To summarize FBXO9 regulation mechanisms.
  • To highlight FBXO9 as a potential target for anticancer therapies.

Main Methods:

  • Literature review of studies on FBXO9 expression, function, and regulation in cancer.
  • Analysis of FBXO9's involvement in cellular processes relevant to tumorigenesis.
  • Synthesis of information on targeting F-box proteins for cancer treatment.

Main Results:

  • FBXO9 influences cell proliferation, cell cycle, apoptosis, migration, invasion, and metastasis.
  • Its role in cancer is context-dependent, affecting oncogenes and tumor suppressors.
  • FBXO9's precise functions require further investigation.

Conclusions:

  • FBXO9 plays a significant, albeit complex, role in human cancer development and progression.
  • Understanding FBXO9 regulation is crucial for developing targeted cancer therapies.
  • Targeting FBXO9 or its pathways offers a promising strategy for cancer treatment.
Keywords:
E3 ubiquitin ligaseF-box only protein 9F-box proteinTumorigenesisUbiquitination

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