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Anti-lung Cancer Marine Compounds: A Review
Mohammad Reza Miri1, Afshin Zare1, Jamileh Saberzadeh2,3
1The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran.
Abstract:
Lung cancer is one of the most common and lethal cancers in human beings. Lung cancer has been divided into two major types: small cell lung cancer (SCLC) and non-small cell lung carcinoma (NSCLC). Current drugs suffer from various side effects, and the insufficient efficacy of present treatments creates a desire for better more efficient new drugs. This review compares the diversity of marine-derived bioactive compounds from different marine species. Some of the natural products from marine resources are in different stages of clinical trials. By the way, most of them have been studied in vitro and in vivo. Additionally, in this review, the mechanisms of action of marine-derived anti-lung cancer components on lung cancer cell lines have been reviewed. In addition, considering growing rate and the high costs of cancer research, attention must be paid to some aspects of targeting and developing anti-lung cancer drug. In better words, like the other therapeutic strategies that have their particular challenges and weak points, several challenges about marine-derived anti-lung cancer components which exist for scientists for doing research are explained. Moreover, as the attentions in the field of cancer therapy are focused on designing and developing new anticancer strategies for the treatment of cancer in the future, the application of marine-derived anti-lung cancer components in the field of future cancer therapy and their role in future anticancer strategies are briefly discussed.
Insights
Marine-derived compounds show promise as novel anti-lung cancer drugs, offering potential alternatives to current treatments. This review explores their efficacy, mechanisms, and challenges for future cancer therapy development.
Area of Science:
- Marine Biotechnology
- Pharmacology
- Oncology
Background:
- Lung cancer remains a leading cause of cancer-related mortality worldwide.
- Existing treatments for small cell lung cancer (SCLC) and non-small cell lung carcinoma (NSCLC) have limitations, including side effects and insufficient efficacy.
- There is a critical need for novel, more effective anti-lung cancer therapeutics.
Purpose of the Study:
- To review and compare diverse marine-derived bioactive compounds with anti-lung cancer properties.
- To examine the mechanisms of action of these marine compounds against lung cancer cell lines.
- To discuss the challenges and future applications of marine-derived anti-lung cancer agents in drug development.
Main Methods:
- Comprehensive literature review of marine-derived natural products with reported anti-lung cancer activity.
- Analysis of in vitro and in vivo studies on the efficacy of these compounds.
- Review of documented mechanisms of action against lung cancer cell lines.
Main Results:
- A variety of marine species yield bioactive compounds with demonstrated anti-lung cancer potential.
- Several marine-derived compounds are progressing through preclinical and clinical trials.
- Mechanisms of action involve diverse pathways relevant to cancer cell inhibition.
Conclusions:
- Marine-derived compounds represent a promising source for developing new anti-lung cancer drugs.
- Further research into their mechanisms and targeted development is crucial.
- These natural products hold significant potential for future cancer therapy strategies.
