Carbon-Based Sorbent Coatings for the Determination of Pharmaceutical Compounds by Bar Adsorptive Microextraction

Thirteen carbon materials comprising commercial activated carbons and lab-made materials (activated carbons, hydrochars, and low-T and high-T activated hydrochars) were assayed as sorbent coatings in bar adsorptive microextration (BAμE) to monitor trace levels of ten common pharmaceutical compounds (PhCs) in environmental water matrices including surface water, seawater, tap water, and wastewater. Polar and nonpolar pharmaceuticals were selected, sulfamethoxazole, triclosan, carbamazepine, diclofenac, mefenamic acid, 17-α-ethinylestradiol, 17-β-estradiol, estrone, gemfibrozil, and clofibric acid, as model compounds to cover distinct therapeutic classes. Despite having a less-developed porosity, data showed that "in-house" prepared low-T activated hydrochars, obtained from carbohydrates and an eutectic salt mixture at low temperature (i.e., 180 °C) and autogenerated pressure, compete with the best commercial activated carbons for this particular application. The combination of a micro and mesopore network with a rich oxygen-based surface chemistry yielding an acidic nature allowed these low-T activated hydrochars to present the best overall recoveries (between 20.9 and 82.4%) for the simultaneous determination of the ten target PhCs with very distinct chemical properties using high performance liquid chromatography-diode array detection (HPLC-DAD).