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Nanostructured Polymer Monoliths for Biomedical Delivery Applications.

Yihui Xie1, Marc A Hillmyer1

  • 1Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455-0431, United States.

ACS Applied Bio Materials
|January 13, 2022
PubMed
Summary
This summary is machine-generated.

This study introduces nanostructured polymer monoliths made using polymerization-induced microphase separation (PIMS) for controlled drug delivery implants and microneedles. These systems offer tunable drug release and potential for long-term transdermal applications.

Keywords:
drug deliverymedical implantsmicroneedlesnanostructured polymersrelease kineticsself-assembly

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Polymer Chemistry

Background:

  • Drug delivery systems aim to optimize therapeutic agent release for better efficacy and reduced side effects.
  • Implantable drug delivery devices offer sustained and localized therapeutic agent release.
  • Polymerization-induced microphase separation (PIMS) is a technique for creating nanostructured materials.

Purpose of the Study:

  • To investigate nanostructured polymer monoliths synthesized by PIMS as potential implantable drug delivery devices.
  • To develop nanostructured microneedles for efficient and long-term transdermal drug delivery.
  • To evaluate the degradation of poly(lactide) in PIMS monoliths for biomedical applications.

Main Methods:

  • Synthesized nanostructured polymer monoliths using polymerization-induced microphase separation (PIMS).
  • Incorporated free poly(ethylene oxide) homopolymers into polystyrene matrix for drug release studies.
  • Developed nanostructured microneedles by combining PIMS and microfabrication techniques.
  • Assessed the degradation rate of microphase-separated poly(lactide) in PIMS monoliths.

Main Results:

  • Investigated *in vitro* release of poly(ethylene oxide) from monoliths based on loading, molar mass, and PIMS parameters.
  • Successfully developed nanostructured microneedles for transdermal drug delivery.
  • Evaluated and compared the degradation rates of PIMS-formed poly(lactide) with bulk poly(lactide).

Conclusions:

  • Nanostructured polymer monoliths synthesized by PIMS show promise as implantable drug delivery devices.
  • PIMS combined with microfabrication offers a route to advanced microneedle-based transdermal delivery systems.
  • The degradation characteristics of PIMS-formed poly(lactide) are relevant for designing long-term implantable devices.