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Self-Assembled DNA Nanostructures-Based Nanocarriers Enabled Functional Nucleic Acids Delivery
Jin Huang1,2,3,4, Wenjie Ma1,2,3,4, Huanhuan Sun1,2,3,4
1College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.
ACS Applied Bio Materials
|January 13, 2022
Summary
Functional nucleic acids (FNAs) show promise for biomedicine, but delivery is challenging. Self-assembled DNA nanostructures offer a solution, acting as nanocarriers for effective FNA delivery in cellular analysis and cancer theranostics.
Area of Science:
- Molecular Biology
- Nanotechnology
- Biomedical Engineering
Background:
- Functional nucleic acids (FNAs) are crucial for genetic information and biological processes.
- Effective delivery of FNAs remains a significant challenge in biomedical applications.
- DNA nanotechnology provides a platform for creating precisely controlled nanostructures.
Purpose of the Study:
- To review the use of self-assembled DNA nanostructures as nanocarriers for functional nucleic acids (FNAs).
- To highlight recent advancements in FNA delivery using DNA nanocarriers for cellular analysis and cancer theranostics.
- To discuss current challenges and future perspectives in this field.
Main Methods:
- Summarizing properties of DNA nanocarriers.
- Introducing self-assembled DNA nanostructures.
- Reviewing recent achievements in FNA delivery via DNA nanostructures.
Main Results:
- Self-assembled DNA nanostructures can be decorated with various FNAs (aptamers, siRNA, ASOs, etc.).
- These DNA nanostructures serve as effective nanocarriers for FNA delivery.
- Applications include cellular analysis and cancer theranostics.
Conclusions:
- Self-assembled DNA nanostructures are promising nanocarriers for functional nucleic acids.
- Further research is needed to overcome current challenges in FNA delivery systems.
- Future perspectives include enhanced applications in bioimaging, biosensing, and targeted therapies.
