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Development of a Gaze-Contingent Display Framework Designed for Perceptual and Oculomotor Research with Simulated Central Vision Loss

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Scotopic microperimetry: evolution, applications and future directions.

Laura J Taylor¹, Amandeep S Josan¹, Maximilian Pfau²

¹Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.

Clinical & Experimental Optometry

|January 13, 2022

Summary

This summary is machine-generated.

Scotopic microperimetry offers detailed mapping of night vision sensitivity, distinguishing rod and cone function. This new visual function test aids early detection of retinal diseases and serves as a valuable clinical trial outcome measure.

Keywords:

Dark-adaptation Fundus-controlled perimetry Scotopic microperimetry microperimetry rods

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Area of Science:

Ophthalmology and Vision Science
Retinal Imaging and Electrophysiology

Background:

Reduced night vision is a key symptom in many inherited and acquired retinal diseases.
Clinical testing for spatially resolved scotopic vision was previously limited.
Scotopic microperimetry addresses this gap by assessing night vision function.

Approach:

Scotopic microperimetry combines two-colour perimetry with fundus-controlled perimetry under scotopic conditions.
It maps central retinal sensitivity with the ability to differentiate rod and cone photoreceptor function.
Commercially available devices from Nidek and CenterVue facilitate its clinical application.

Key Points:

This technique provides spatially resolved mapping of retinal sensitivity in low light.
It can detect subtle changes in retinal sensitivity earlier than other visual function measures.
Scotopic microperimetry serves as a promising functional biomarker for retinal diseases.

Conclusions:

Scotopic microperimetry represents a significant advancement in assessing night vision.
It has the potential to be a valuable outcome measure in clinical trials for retinal diseases.
This review covers the evolution, applications, and testing parameters of scotopic microperimetry.