Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

149
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
149
Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

89
Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
89

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Photon-counting Detector CT Spectral Reconstructions for Radiomics-based Liver Lesion Classification: A Multicenter Study.

Investigative radiology·2026
Same author

Advanced Iterative Metal Artifact Reduction With Intrinsic Spectral Information From Photon-counting Detector Computed Tomography: Improving the Assessment of Metal-bone Interface.

Investigative radiology·2026
Same author

High-Z Contrast Media for Coronary Photon-counting Detector CT Angiography: Improved Quantification of Calcified Stenoses.

Investigative radiology·2026
Same author

Photon-counting CT-derived hepatic extracellular volume quantification for noninvasive risk stratification of clinically significant portal hypertension (CSPH): a prospective cohort study.

European radiology·2025
Same author

Photon-counting detector computed tomography compared with cardiac magnetic resonance imaging for myocardial extracellular volume quantification in spontaneous coronary artery dissection.

Scientific reports·2025
Same author

Multicontrast Multiphase Intestinal Imaging Using Photon-Counting CT: A Feasibility Study in Rats.

Investigative radiology·2025

Related Experiment Video

Updated: Oct 6, 2025

Retrospective Cardiac Gating with A Prototype Small-Animal X-ray Computed Tomograph
05:32

Retrospective Cardiac Gating with A Prototype Small-Animal X-ray Computed Tomograph

Published on: February 21, 2025

453

Photon-Counting Detector CT-Based Vascular Calcium Removal Algorithm: Assessment Using a Cardiac Motion Phantom.

Thomas Allmendinger1, Tristan Nowak1, Thomas Flohr

  • 1From Siemens Healthcare GmbH, Forchheim.

Investigative Radiology
|January 13, 2022
PubMed
Summary
This summary is machine-generated.

A new PureLumen algorithm for photon-counting detector computed tomography (PCD-CT) significantly improves coronary artery stenosis assessment by reducing calcium blooming artifacts. This novel approach maintains image quality in simulated cardiac motion up to 80 bpm.

More Related Videos

Author Spotlight: Advancing Cardiovascular Imaging - Introducing the Spatially Weighted Calcium Score for Early Disease Detection
06:57

Author Spotlight: Advancing Cardiovascular Imaging - Introducing the Spatially Weighted Calcium Score for Early Disease Detection

Published on: September 22, 2023

1.2K
Author Spotlight: Enhanced Quantification of Cardiovascular Calcification Progression for Longitudinal Micro PET/CT Studies in Small Research Animals
08:02

Author Spotlight: Enhanced Quantification of Cardiovascular Calcification Progression for Longitudinal Micro PET/CT Studies in Small Research Animals

Published on: November 15, 2024

749

Related Experiment Videos

Last Updated: Oct 6, 2025

Retrospective Cardiac Gating with A Prototype Small-Animal X-ray Computed Tomograph
05:32

Retrospective Cardiac Gating with A Prototype Small-Animal X-ray Computed Tomograph

Published on: February 21, 2025

453
Author Spotlight: Advancing Cardiovascular Imaging - Introducing the Spatially Weighted Calcium Score for Early Disease Detection
06:57

Author Spotlight: Advancing Cardiovascular Imaging - Introducing the Spatially Weighted Calcium Score for Early Disease Detection

Published on: September 22, 2023

1.2K
Author Spotlight: Enhanced Quantification of Cardiovascular Calcification Progression for Longitudinal Micro PET/CT Studies in Small Research Animals
08:02

Author Spotlight: Enhanced Quantification of Cardiovascular Calcification Progression for Longitudinal Micro PET/CT Studies in Small Research Animals

Published on: November 15, 2024

749

Area of Science:

  • Medical Imaging
  • Radiology
  • Cardiovascular Imaging

Background:

  • Diagnostic performance of coronary computed tomography angiography (CCTA) is compromised by severe coronary artery calcifications.
  • Calcified plaques cause blooming artifacts, hindering accurate stenosis assessment in CCTA.
  • Novel image reconstruction algorithms are needed to overcome limitations of traditional methods.

Purpose of the Study:

  • To evaluate the performance of a novel calcium-removal algorithm, PureLumen, for spectral computed tomography (CT) data.
  • To assess PureLumen's effectiveness in reducing artifacts from calcified plaques in coronary arteries.
  • To investigate the impact of simulated cardiac motion on PureLumen's image quality and diagnostic accuracy.

Main Methods:

  • A phantom study using a first-generation dual-source photon-counting detector CT (PCD-CT) system.
  • Two vessel phantoms with varying iodine concentrations and calcified stenosis inserts (25% and 50% PDS) were used.
  • Images were reconstructed using standard virtual monoenergetic images (Mono) and the PureLumen algorithm at 65 keV, with and without simulated cardiac motion (50-100 bpm).

Main Results:

  • PureLumen significantly improved the accuracy of stenosis grading for both 25% and 50% lesions compared to Mono reconstruction (P < 0.05).
  • Median PDS values for the 50% lesion were closer to true values with PureLumen (50.0%) than Mono (56.0%).
  • Good image quality was maintained with PureLumen up to a simulated heart rate of 80 bpm.

Conclusions:

  • The PureLumen algorithm effectively reduces blooming artifacts from coronary calcifications, enhancing image interpretability in PCD-CT.
  • PureLumen demonstrates robust performance under simulated cardiac motion, up to 80 bpm.
  • Further in vivo studies are warranted to confirm the clinical benefits of PureLumen for CCTA quality and accuracy.