Related Experiment Video

Updated: Oct 6, 2025

The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers
12:22

The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers

Published on: January 22, 2013

33.8K

The value of erlotinib related target molecules in kidney renal cell carcinoma via bioinformatics analysis

YunQiang Zhang1, MingYang Tang2, Qiang Guo3

  • 1Department of Thoracic Surgery, Beilun District people's Hospital of Ningbo, Ningbo, Zhejiang 315800, China.

Gene
|January 13, 2022
PubMed
Abstract

Insights

Erlotinib shows promise for metastatic kidney renal cell carcinoma (KIRC). Bioinformatics identified key genes (COL11A1, EMCN, etc.) linked to KIRC prognosis and immune infiltration, aiding in risk assessment.

Area of Science:

  • Oncology
  • Bioinformatics
  • Genomics

Background:

  • Erlotinib is an effective treatment for metastatic kidney renal cell carcinoma (KIRC).
  • Understanding erlotinib's molecular targets is crucial for improving KIRC treatment strategies.
  • Bioinformatic approaches can identify novel biomarkers for cancer prognosis.

Purpose of the Study:

  • To explore the prognostic value of erlotinib's target molecules in kidney renal cell carcinoma (KIRC).
  • To identify key genes associated with patient outcomes and immune infiltration in KIRC.
  • To develop a predictive model for KIRC prognosis based on erlotinib's molecular targets.

Main Methods:

  • Differential gene expression analysis of GSE25698 dataset after erlotinib treatment.
  • Functional enrichment analysis of differentially expressed genes (DEGs).
  • Construction of a prognostic risk model and nomogram using TCGA database and DEG analysis.

Main Results:

  • DEGs after erlotinib treatment were involved in antigen binding, myeloid cell activation, and JAK-STAT signaling.
  • Ten genes (COL11A1, EMCN, GLYATL1, HHLA2, IGFN1, LIPA, LRRC19, PANK1, PRAME, TNFSF14) were independent predictors of poor KIRC prognosis.
  • The risk score correlated with immune cell infiltration (e.g., regulatory T cells, M0 macrophages) and various signaling pathways (e.g., MAPK, apoptosis).

Conclusions:

  • The identified genes (COL11A1, EMCN, etc.) are significantly associated with KIRC prognosis and immune infiltration.
  • A risk model and nomogram incorporating erlotinib's target molecules can aid in evaluating KIRC patient prognosis.
  • These findings provide a basis for personalized treatment strategies in KIRC.
Keywords:
DEGsErlotinibKIRCNomogramRisk model

More Related Videos

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization03:08

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

Published on: October 3, 2025

5
Discrimination and Characterization of Heterocellular Populations Using Quantitative Imaging Techniques09:48

Discrimination and Characterization of Heterocellular Populations Using Quantitative Imaging Techniques

Published on: June 30, 2017

7.6K

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.9K
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.2K