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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
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Updated: Oct 6, 2025

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Ganoderma modulates allergic asthma pathologic features via anti-inflammatory effects.

Yanfeng Li1, Miaomiao Li1, Rui Wang1

  • 1Department of Traditional Chinese Medicine, Xidian Group Hospital, Xi'an City, 710077, People's Republic of China.

Respiratory Physiology & Neurobiology
|January 13, 2022
PubMed
Summary
This summary is machine-generated.

Ganoderma extract reduced airway inflammation and key inflammatory markers in an asthma model. This study suggests Ganoderma

Keywords:
AirwayAllergyGanodermaInflammationTraditional medicine

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Area of Science:

  • Immunology
  • Pharmacology
  • Respiratory Medicine

Background:

  • Asthma is a chronic airway inflammatory disease often triggered by allergic inflammation.
  • Ganoderma, a traditional medicinal fungus, exhibits immunomodulatory properties.

Purpose of the Study:

  • To evaluate the anti-inflammatory and immunomodulatory effects of Ganoderma in a murine model of asthma.
  • To assess the impact of Ganoderma administration via oral (G/O) and intraperitoneal (G/IP) routes on asthma-related biomarkers and lung pathology.

Main Methods:

  • Asthma was induced in BALB/c mice using ovalbumin (OVA) challenge.
  • Mice were treated with Ganoderma (G/O or G/IP) or served as controls.
  • Airway hyperresponsiveness (AHR) was measured via MCh challenge.
  • Cytokine levels (IL-1β, -4, -5, -6, -8, -10, -12, -13, -17, -25, -33, -38), Cys-LT, LTB4, and hydroxyproline were quantified.
  • Lung histopathology was analyzed for eosinophilic inflammation, goblet cell hyperplasia, and mucus hyper-secretion.

Main Results:

  • Ganoderma treatment (G/O and G/IP) significantly reduced levels of IL-1β, -5, -6, -8, -17, -25, -33, and -38.
  • Levels of IL-4 and IL-13 remained unchanged, while IL-10 and IL-12 were enhanced.
  • Cys-LT, LTB4, and inflammatory infiltrates in lung tissue were decreased.
  • No significant changes were observed in AHR, hydroxyproline levels, goblet cell hyperplasia, or mucus hyper-secretion.

Conclusions:

  • Ganoderma demonstrates significant immunomodulatory and anti-inflammatory effects in an experimental asthma model.
  • Oral and intraperitoneal administration of Ganoderma can mitigate key inflammatory pathways involved in asthma.
  • Ganoderma holds potential as a therapeutic agent for managing asthma.