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Updated: Oct 6, 2025
Author Spotlight: Metallic Nanocomposites to Eliminate Antibiotic-Resistant Bacteria
Published on: October 4, 2024
Ultrahigh-efficiency antibacterial and adsorption performance induced by copper-substituted
Cuili Xing1, Jiangnan Chang1, Min Ma1
1Henan Key Laboratory of Polyoxometalate Chemistry, Institute of Molecular and Crystal Engineering, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, Henan 475004, PR China.
Abstract:
Given the rise of drug-resistant pathogens and industrial contaminants, the development of efficient and eco-friendly water treatment technologies and materials is highly desirable and urgent. Herein, a multifunctional graphene oxide/chitosan/copper-based polyoxometalate (GO/CS/Cu-POM) nanocomposite (Cu-POM, [Cu(L)4][Cu(L)3(H2O)][Cu(L)(H2O)][P2Mo5O23]·4H2O, L = pyrazole) was synthesized by the ultrasound-assisted self-assembly strategy. The GO/CS/Cu-POM nanocomposite exhibited potent bactericidal properties against gram-positive/negative bacterial strains Staphylococcus aureus (S. aureus, 99.98%), Escherichia coli (E. coli, 99.99%), and drug-resistant E. coli bacterial strains (kanamycin-resistant E. coli 99.93% and ampicillin-resistant E. coli, 97.94%). Further, the antibacterial performance was strongly dependent on synergistic effect between GO/CS and Cu-POM in GO/CS/Cu-POM. The destruction of bacterial membrane and high levels of oxidative stress induced by GO/CS/Cu-POM played a significant role in the bactericidal process. Furthermore, the GO/CS/Cu-POM nanocomposite also displayed superior performance for removal of methylene blue (MB, 96.86%), gentian violet (GV, 97.77%), basic fuchsin (BF, 96.47%), tetracycline (TC, 78.92%) and norfloxacin (NC, 76.26%). Moreover, the main process of dye removal by GO/CS/Cu-POM was controlled by chemisorption. More importantly, the GO/CS/Cu-POM nanocomposite indicated good biocompatibility to human umbilical vein endothelial cells. Current work provides an effective strategy to design multifunctional POM-based composites for water purification and environmental protection.
