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Related Experiment Videos

Bone turnover in spinal osteoporosis.

J Pødenphant1, J S Johansen, K Thomsen

  • 1Department of Clinical Chemistry, University of Copenhagen, Glostrup Hospital, Denmark.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
|December 1, 1987
PubMed
Summary

Biochemical markers reveal that postmenopausal osteoporosis involves increased bone resorption and potentially reduced bone formation. Bone Gla protein (pBGP) and serum alkaline phosphatase (sAP) correlate with bone formation histology.

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Area of Science:

  • Biochemistry
  • Bone Metabolism
  • Gerontology

Background:

  • Postmenopausal osteoporosis is characterized by altered bone turnover.
  • Biochemical and histomorphometric markers are used to assess bone formation and resorption.

Purpose of the Study:

  • To investigate biochemical indices of bone formation and resorption in postmenopausal women with spinal fractures.
  • To compare these indices with histomorphometric data and normal subjects.
  • To explore the relationship between biochemical markers and bone turnover in aging and osteoporosis.

Main Methods:

  • Measured serum alkaline phosphatase (sAP), plasma bone Gla protein (pBGP), urinary hydroxyproline/creatinine (FuHP/Cr), and urinary calcium/creatinine (FuCa/Cr).
  • Determined histomorphometric indices of bone resorption and formation.

Related Experiment Videos

  • Assessed whole body retention (WBR) of 99m-technetium-diphosphonate (99mTc-DP).

    • Main Results:

    • Bone formation markers (sAP, WBR, pBGP) increased with age.
    • Osteoporotic patients showed lower pBGP and likely lower histological bone formation compared to controls.
    • Biochemical bone resorption indices were high in osteoporotics but poorly correlated with histological resorption.

    Conclusions:

    • Bone turnover increases with aging.
    • Osteoporotic patients exhibit higher bone resorption and potentially lower bone formation.
    • pBGP and sAP may reflect different aspects of osteoblastic activity and bone mineralization.