Long-term experience and Visual Acuity outcomes in Peters Anomaly cases
R Donoso Rojas1, J P López Garin1, G Jara Urrutia2
1Hospital del Salvador, Santiago, Chile.
Archivos De La Sociedad Espanola De Oftalmologia
|January 14, 2022
Summary
Peters Anomaly management varies by type, with Type I cases requiring only medical monitoring showing the best visual outcomes. Surgical interventions like optical iridectomy and penetrating keratoplasty (PKP) in Peters Anomaly cases yield less favorable prognoses.
Area of Science:
- Ophthalmology
- Genetics
- Pediatric Ophthalmology
Background:
- Peters Anomaly is a rare congenital corneal defect.
- It is characterized by the absence of the posterior limiting membrane of the cornea and Descemet's membrane.
- Management strategies are tailored to the specific type and severity of the anomaly.
Purpose of the Study:
- To analyze outcomes in a series of Peters Anomaly cases.
- To propose tailored management and treatment approaches based on associated ocular alterations.
- To correlate visual acuity (VA) and long-term corneal outcomes with Peters Anomaly type.
Main Methods:
- Retrospective analysis of 27 patients (32 eyes) diagnosed with Peters Anomaly.
- Patients received varied treatments, from medical management to Penetrating Keratoplasty (PKP).
- Long-term visual acuity and corneal graft survival were assessed.
Main Results:
- The study included 74% males and 26% females, with 18.5% bilateral and 81.5% unilateral cases.
- Mean follow-up was 10.2 years.
- Visual acuity (VA) outcomes correlated with Peters Anomaly type: Type I (medical monitoring) LogMAR 0.3, Type I (OI) LogMAR 0.97, Type I (PKP) LogMAR 1.22, Type II (PKP, no posterior pole compromise) LogMAR 2.41, Type II (PKP, posterior pole compromise) LogMAR 2.56.
Conclusions:
- Visual acuity and corneal graft survival in Peters Anomaly are directly related to the anomaly type.
- Type I Peters Anomaly managed solely with medical follow-up demonstrated the most favorable prognosis.
- Surgical interventions, including optical iridectomy and PKP, were associated with less favorable outcomes.
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