Related Experiment Video
Updated: Oct 6, 2025

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
Published on: June 15, 2019
Coagulome and the tumor microenvironment: an actionable interplay
Antoine Galmiche1, Janusz Rak2, Lubka T Roumenina3
1Laboratoire de Biochimie, Centre de Biologie Humaine, CHU Sud, Amiens, France; UR7516 'CHIMERE', Université de Picardie Jules Verne, Amiens, France.
Human tumors create a hypercoagulable state, increasing risks of blood clots. Studying the coagulome and tumor microenvironment (TME) interactions may improve cancer treatment and predict hemostatic complications.
Area of Science:
- Oncology
- Hematology
- Systems Biology
Background:
- Human tumors frequently induce a hypercoagulable state, leading to hemostatic complications like venous thromboembolism.
- Systems biology approaches have revealed a connection between the coagulome and the tumor microenvironment (TME).
Purpose of the Study:
- To explore the interplay between the coagulome and TME.
- To reassess the utility of hemostasis biomarkers in cancer.
- To investigate tumor-vasculature communication in light of new cancer therapies.
Main Methods:
- Systems biology analysis of the coagulome.
- Investigation of hemostasis biomarkers.
- Assessment of tumor-vasculature communication.
Main Results:
- The coagulome significantly influences the TME, both intravascularly and extravascularly.
- Understanding coagulome-TME interactions offers new therapeutic and predictive avenues.
Conclusions:
- The link between the coagulome and TME is crucial for understanding cancer progression and complications.
- Targeting this interaction may enhance cancer treatment efficacy and predict hemostatic risks.
More Related Videos
09:52A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
Published on: September 20, 2016
07:46Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments
Published on: April 30, 2021
Related Concept Videos
The Tumor Microenvironment
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Immunotherapy
Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Metastasis
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Regulation of Angiogenesis and Blood Supply