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Elevated plasma macrophage migration inhibitor factor is associated with hypertension and hypertensive left

Ling Zhu1,2, Shasha Chen3, Na Liu4

  • 1Department of Cardiology, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, 710000, China.

Journal of Human Hypertension
|January 14, 2022
PubMed

Insights

Elevated macrophage migration inhibitor factor (MIF) is linked to hypertension and hypertensive left ventricular hypertrophy. Higher MIF levels significantly increase the risk of developing these cardiovascular conditions.

Area of Science:

  • Cardiovascular Research
  • Biomarkers
  • Hypertension Research

Background:

  • Macrophage migration inhibitor factor (MIF) is implicated in endothelial dysfunction and ventricular remodeling.
  • Understanding MIF's role in hypertension and associated cardiac changes is crucial for cardiovascular health.

Purpose of the Study:

  • To investigate the association between plasma MIF levels and the presence of hypertension.
  • To explore the relationship between plasma MIF levels and hypertensive left ventricular hypertrophy (LVH).

Main Methods:

  • A cohort of 308 participants, including 187 hypertensive patients and 121 healthy controls, was studied.
  • Univariate and multivariate logistic regression models were used to assess associations.
  • Correlation and receiver operating characteristic (ROC) analyses were performed.

Main Results:

  • Elevated MIF levels were significantly associated with an increased risk of hypertension.
  • Plasma MIF levels strongly correlated with hypertensive left ventricular mass index (r=0.580, P<0.001).
  • Higher MIF levels were strongly associated with hypertensive LVH, with significant odds ratios (e.g., OR 24.95 for the highest tertile).
  • ROC analysis showed MIF has good predictive accuracy for hypertensive LVH (AUC=0.84).

Conclusions:

  • Elevated plasma macrophage migration inhibitor factor is a significant risk factor for hypertension.
  • Increased MIF levels are closely associated with hypertensive left ventricular hypertrophy, suggesting its role as a potential biomarker.

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