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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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A 3D Organotypic Melanoma Spheroid Skin Model
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Evolution in Sinonasal Mucosal Melanoma Management.

Tony Richa1, Alice Lee1, Marc A Cohen1

  • 1Department of Head and Neck Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, United States.

Journal of Neurological Surgery Reports
|January 14, 2022
PubMed
Summary

Sinonasal mucosal melanoma is a rare, aggressive cancer. Current treatments like surgery and radiation offer limited success, necessitating novel therapeutic strategies and further clinical trials.

Keywords:
immunotherapymanagementmelanomareviewsinonasal mucosal melanoma

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Area of Science:

  • Oncology
  • Head and Neck Surgery
  • Cancer Research

Background:

  • Sinonasal mucosal melanoma is a rare malignancy with aggressive behavior and poor patient outcomes.
  • Current treatment modalities including surgery, radiation, chemotherapy, and immunotherapy demonstrate limited efficacy.
  • There is a critical need for novel therapeutic approaches and further clinical investigation.

Purpose of the Study:

  • To present a unique case of advanced sinonasal mucosal melanoma.
  • To provide a comprehensive overview of current literature regarding the management of this rare cancer.
  • To highlight the limitations of existing treatments and the need for new therapeutic strategies.

Main Methods:

  • Case report of a patient with advanced sinonasal mucosal melanoma.
  • Literature review of recent studies on sinonasal mucosal melanoma management.
  • Analysis of treatment outcomes and prognostic factors.

Main Results:

  • Surgical resection with clear margins is the primary treatment when feasible.
  • Adjuvant radiation therapy improves local control after complete resection.
  • Chemotherapy and immunotherapy have shown limited success in improving locoregional control and survival.

Conclusions:

  • Advanced sinonasal mucosal melanoma presents significant therapeutic challenges.
  • Existing treatments offer suboptimal outcomes, underscoring the need for innovative agents.
  • Further prospective trials are essential to improve management and patient prognosis.