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Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
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Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
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Related Experiment Video

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Collection, Isolation, and Flow Cytometric Analysis of Human Endocervical Samples
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Plasma cell vulvitis: A systematic review.

Samantha Sattler1, Ashley N Elsensohn2, Melissa M Mauskar3

  • 1Albany Medical College, Albany, New York.

International Journal of Women'S Dermatology
|January 14, 2022
PubMed
Summary

Plasma cell vulvitis (PCV) is an underrecognized inflammatory condition. Early diagnosis and treatment with topical corticosteroids or tacrolimus are recommended for this vulvar dermatosis.

Keywords:
Plasma cell mucositisPlasma cell vulvitisVulvar diseaseZoon's vulvitis

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Area of Science:

  • Dermatology
  • Gynecology
  • Pathology

Background:

  • Plasma cell vulvitis (PCV) is an inflammatory vulvar dermatosis lacking comprehensive characterization.
  • Delayed diagnosis and treatment resistance are common challenges in managing PCV.
  • This study addresses the absence of systematic reviews on PCV.

Purpose of the Study:

  • To conduct a systematic review of plasma cell vulvitis (PCV).
  • To synthesize epidemiologic, clinical, and histopathologic findings.
  • To identify associated comorbidities and evaluate treatment options for PCV.

Main Methods:

  • A systematic literature search was performed across major medical databases (PubMed, Ovid Medline, Cochrane, CINAHL).
  • Included studies comprised 53 publications detailing 196 patients diagnosed with PCV.
  • Data extraction focused on demographics, clinical presentation, histopathology, and treatment outcomes.

Main Results:

  • Common symptoms included burning/stinging (52%), dyspareunia (44%), and pruritus (41%).
  • Key clinical findings were erythema (84%), glistening appearance (29%), and erosions (22%).
  • Histopathology frequently showed plasma cell infiltrate (88%), hemosiderin (46%), and epidermal atrophy (43%). Topical corticosteroids (64%) and tacrolimus (13%) were primary treatments.

Conclusions:

  • PCV is likely underrecognized, characterized by vulvar erythema, burning, and plasma cell infiltrates.
  • High-potency topical corticosteroids (clobetasol) or tacrolimus ointment are recommended first-line therapies.
  • Further prospective studies are essential for developing definitive treatment guidelines for PCV.