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Updated: Oct 6, 2025

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
Published on: January 26, 2018
Histone modifications in neurodifferentiation of embryonic stem cells
Min Huang1, Xiaoxiao Xiao1, Guanxu Ji1
1The State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macao SAR, China.
Abstract:
Post-translational modifications of histone proteins regulate a long cascade of downstream cellular activities, including transcription and replication. Cellular lineage differentiation involves large-scale intracellular signaling and extracellular context. In particular, histone modifications play instructive and programmatic roles in central nervous system development. Deciphering functions of histone could offer feasible molecular strategies for neural diseases caused by histone modifications. Here, we review recent advances of in vitro and in vivo studies on histone modifications in neural differentiation.
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