Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

CNS Depressants: Alcohol and Nicotine01:27

CNS Depressants: Alcohol and Nicotine

472
Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
472
Drugs Affecting Neurotransmitter Synthesis01:29

Drugs Affecting Neurotransmitter Synthesis

1.7K
Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase,...
1.7K
Types of RNA01:20

Types of RNA

6.8K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
6.8K
Drugs Affecting Neurotransmitter Release or Uptake01:21

Drugs Affecting Neurotransmitter Release or Uptake

1.3K
Certain drugs can affect how neurotransmitters called catecholamines, are released or taken back up in the adrenergic neuron. They can have different effects on the body's sympathetic transmission. Reserpine, a natural compound found in the Rauwolfia shrub, blocks a transporter called vesicular monoamine transporter (VMAT), which leads to a buildup of catecholamines in the cell and reduces sympathetic transmission. Another drug called guanethidine works in multiple ways, including blocking...
1.3K
Role of Neurotransmitters in Memory01:23

Role of Neurotransmitters in Memory

1.3K
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
 Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
1.3K
Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

780
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
780

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multicenter external validation of normal tissue complication probability models for radiation-induced primary hypothyroidism in head and neck cancer survivors with long-term endocrine outcomes.

International journal of radiation oncology, biology, physics·2026
Same author

Integrative single-cell and spatial transcriptomic analysis reveals that ATG13 enriched in cancer-associated fibroblasts is associated with the suppression of ferroptosis in colorectal cancer.

Discover oncology·2026
Same author

InnerEye-HS: a disease-agnostic clinical tool for hippocampal segmentation.

Brain communications·2026
Same author

Al─N Co-Doped LLZO Solid Electrolytes via One-Step Sintering: Toward High Ionic Conductivity.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Multi-omics biomarkers in endometrial receptivity: from mechanisms to clinical translation.

Journal of translational medicine·2026
Same author

Quality and consistency of genetic newborn screening reports in China: insights from a multi-laboratory analysis using simulated samples.

BMC pediatrics·2026

Related Experiment Video

Updated: Oct 6, 2025

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
05:12

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

1.1K

Non-coding RNA in alcohol use disorder by affecting synaptic plasticity.

Shuang Zhu1, Jiaming Wu2, Jian Hu3,3

  • 1Mental Health Institute, First Affiliated Hospital Medical University, Harbin, Heilongjiang, China.

Experimental Brain Research
|January 14, 2022
PubMed
Summary

Non-coding RNAs (ncRNAs) are crucial in alcohol use disorder (AUD) development. These molecules regulate gene expression and brain function, offering potential as biomarkers and therapeutic targets for AUD.

Keywords:
AlcoholNon-coding RNAsSynaptic plasticity

More Related Videos

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
09:29

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

2.3K
Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
09:26

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

19.0K

Related Experiment Videos

Last Updated: Oct 6, 2025

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
05:12

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

1.1K
Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
09:29

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

2.3K
Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
09:26

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

19.0K

Area of Science:

  • Neuroscience
  • Genetics
  • Molecular Biology

Background:

  • Alcohol use disorder (AUD) is a significant global public health issue.
  • Genetic factors play a critical role in AUD susceptibility and progression.
  • Alcohol metabolism influences epigenetic inheritance, impacting brain function and addiction severity.

Purpose of the Study:

  • To review the regulatory roles of non-coding RNAs (ncRNAs) in the context of alcohol addiction.
  • To explore how ncRNAs mediate epigenetic modifications and synaptic plasticity in chronic AUD.
  • To discuss the potential of ncRNAs as diagnostic predictors and therapeutic targets for AUD.

Main Methods:

  • Literature review focusing on ncRNA involvement in alcohol use disorder.
  • Analysis of studies investigating ncRNA regulation of gene expression, epigenetics, and synaptic plasticity.
  • Examination of ncRNA's role in the transition from alcohol use to dependence.

Main Results:

  • ncRNAs, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), are integral to AUD pathogenesis.
  • Alcohol consumption alters ncRNA expression, affecting epigenetic mechanisms and synaptic plasticity, thereby influencing addiction.
  • Dysregulated ncRNA-mRNA networks and epigenetic changes contribute to alcohol-induced pathological brain alterations.

Conclusions:

  • ncRNAs are key players in the development and progression of alcohol use disorder.
  • ncRNAs are implicated in alcohol-induced neuroimmune disorders and brain dysfunction.
  • ncRNAs represent promising biomarkers for predicting therapeutic responses and novel targets for AUD treatment.