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Related Concept Videos

Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
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Imaging Studies for Cardiovascular System V: CT01:28

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Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
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Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
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Imaging Studies for Cardiovascular System III: X-Ray01:20

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The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
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An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
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Imaging Studies for Cardiovascular System II:Types of Echocardiography01:20

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Echocardiography plays a role in assessing cardiac health and detecting heart conditions, with various types providing critical insights for diagnosis and treatment.
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PET Tracers for Imaging Cardiac Function in Cardio-oncology.

James M Kelly1,2, John W Babich3,4,5

  • 1Division of Radiopharmaceutical Sciences and Molecular Imaging Innovations Institute (MI3), Weill Cornell Medicine, Belfer Research Building, Room BB-1604, 413 East 69th St, New York, NY, 10021, USA. jak2046@med.cornell.edu.

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Emerging positron emission tomography (PET) tracers show promise for early detection of cancer treatment-related heart damage (cardiotoxicity) before irreversible impairment occurs, improving patient outcomes.

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CardiotoxicityFibroblast activation proteinMetabolic imagingPositron emission tomographySympathetic innervation

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Area of Science:

  • Cardio-oncology
  • Medical Imaging
  • Nuclear Medicine

Background:

  • Cancer therapies can cause cardiotoxicity, leading to heart failure.
  • Early detection of cardiac injury is crucial to prevent irreversible damage.
  • Echocardiography, the current standard, has limitations in detecting early dysfunction.

Purpose of the Study:

  • To review emerging positron emission tomography (PET) tracers for detecting incipient cardiotoxicity.
  • To highlight advancements in imaging for early identification of cardiac impairment during cancer treatment.

Main Methods:

  • Review of emerging PET tracers and radiolabeled probes.
  • Discussion of their application in preclinical models and preliminary clinical evaluations.
  • Exploration of fibroblast activation protein (FAP) targeted probes for cardiac remodeling.

Main Results:

  • Positron-emitting radionuclide-labeled vectors enable detailed cardiac assessment.
  • Emerging PET tracers demonstrate high sensitivity to early cardiac damage.
  • Fibroblast activation protein (FAP) probes show potential for detecting adverse cardiac remodeling.

Conclusions:

  • PET imaging offers a promising avenue for early cardiotoxicity detection.
  • Advancements in PET technology and tracer development can enhance cardio-oncology care.
  • New imaging tools can help mitigate the risk of heart failure in cancer survivors.