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High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
Published on: December 16, 2022
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PET Tracers for Imaging Cardiac Function in Cardio-oncology
James M Kelly1,2, John W Babich3,4,5
1Division of Radiopharmaceutical Sciences and Molecular Imaging Innovations Institute (MI3), Weill Cornell Medicine, Belfer Research Building, Room BB-1604, 413 East 69th St, New York, NY, 10021, USA. jak2046@med.cornell.edu.
Current Cardiology Reports
|January 14, 2022
Summary
Emerging positron emission tomography (PET) tracers show promise for early detection of cancer treatment-related heart damage (cardiotoxicity) before irreversible impairment occurs, improving patient outcomes.
Area of Science:
- Cardio-oncology
- Medical Imaging
- Nuclear Medicine
Background:
- Cancer therapies can cause cardiotoxicity, leading to heart failure.
- Early detection of cardiac injury is crucial to prevent irreversible damage.
- Echocardiography, the current standard, has limitations in detecting early dysfunction.
Purpose of the Study:
- To review emerging positron emission tomography (PET) tracers for detecting incipient cardiotoxicity.
- To highlight advancements in imaging for early identification of cardiac impairment during cancer treatment.
Main Methods:
- Review of emerging PET tracers and radiolabeled probes.
- Discussion of their application in preclinical models and preliminary clinical evaluations.
- Exploration of fibroblast activation protein (FAP) targeted probes for cardiac remodeling.
Main Results:
- Positron-emitting radionuclide-labeled vectors enable detailed cardiac assessment.
- Emerging PET tracers demonstrate high sensitivity to early cardiac damage.
- Fibroblast activation protein (FAP) probes show potential for detecting adverse cardiac remodeling.
Conclusions:
- PET imaging offers a promising avenue for early cardiotoxicity detection.
- Advancements in PET technology and tracer development can enhance cardio-oncology care.
- New imaging tools can help mitigate the risk of heart failure in cancer survivors.
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